Clomiphene citrate improved testosterone and sperm concentration in hypogonadal males
نویسندگان
چکیده
منابع مشابه
Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men.
BACKGROUND Obesity has been associated with low testosterone (T) in adult males and in pubertal boys. Therapy for hypogonadism with exogenous T may lead to testicular atrophy and later infertility. Only a few studies have demonstrated that the Selective Estrogen Receptor Modulator (SERM) clomiphene citrate (CC), an estrogen receptor antagonist, increases T in obese hypogonadal men while prevent...
متن کاملOral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement.
OBJECTIVES To determine the effects of daily oral doses of enclomiphene citrate compared with topical testosterone gel treatment on serum total testosterone (TT), luteinising hormone (LH), follicle-stimulating hormone (FSH), and sperm counts in men with secondary hypogonadism. PATIENTS AND METHODS Two parallel randomised, double-blind, double-dummy, placebo-controlled, multicentre, phase III ...
متن کاملClomiphene Citrate and Oocyte Quality
Ovary is a dynamic organ and generates excess amount of reactive oxygen species (ROS) during follicular growth, development, maturation and ovulation [1]. The increased level of ROS is scavenged by antioxidant systems [2]. A moderate increase of ROS could be beneficial for oocyte meiotic maturation and reproductive outcome [3-5]. Overproduction of ROS or depletion of enzymatic antioxidant syste...
متن کاملTestosterone versus clomiphene citrate in managing symptoms of hypogonadism in men
INTRODUCTION Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. PATIENTS AND METHODS 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for...
متن کاملCLOMID® (clomiphene citrate tablets USP)
Clomiphene citrate is a white to pale yellow, essentially odorless, crystalline powder. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether. CLOMID is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. Each white scored tablet contains 50 m...
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ژورنال
عنوان ژورنال: Systems Biology in Reproductive Medicine
سال: 2020
ISSN: 1939-6368,1939-6376
DOI: 10.1080/19396368.2020.1822457